第六届北京罕见病学术大会暨2018京津冀罕见病学术大会征文（121）

1Department of Neurology， Peking University First Hospital，

2Department of radiology， Peking University First Hospital，

1Zhang WQ， 2Xiao JX， 1Meng LC， 1Lv H， 1Zhang W， 1Yu M， 1Zheng YM， 1Wang ZX， 1Yuan Y.

Charcot-Marie-Tooth disease (CMT) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) are respectively the most frequent inherited and acquired peripheral neuropathy. Differential diagnosis is always big issue for neurologist， because they are longth dependent neuropathy with similar distal muscle weakness and atrophy. Here we compared the muscle magnetic resonance imaging (MRI) features in low legs between CMT and CIDP. Average onset age were 20.8±20.8 years (3-55years) in 5 CMT patients and 25.5±16.2 (9-57years) in 7 CIDP patients. Average disease duration were 5.8±3.89 years (2-10years) in CMT patients and 1.88±1.98 years (0.25-6years) in CIDP patients. In CMT patients， fatty infiltrate was more severe in tibialis anterior， extensor hallucis longus and digitorum longus， peroneus， gastrocnemius and soleus with sparing of tibialis posterior and flexor hallucis/digitorum longus. In CIDP patients， fatty infiltrate was more severe in tibialis posterior， flexor hallucis/digitorum longus， soleus and peroneus with sparing of gastrocnemius， tibialis anterior， extensor hallucis longus and digitorum longus. The Muscle MRI in low legs is useful marker for differential diagnosis between CMT and CIDP.