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Prevalence and perinatal risk factors associated with congenital hypothyroidism: a case-control study

作者:Jin-Qi Zhao 等 日期:2024-05-21 浏览量:66

第十一届北京罕见病学术大会暨2023京津冀罕见病学术大会征文(101)

1Department of Newborn Screening Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, P. R. China.

2Division of Endocrinology and Metabolism, Department of ObstetricsBeijing Obstetrics and Gynecology HospitalCapital Medical UniversityBeijing, P. R. China.

Jin-Qi Zhao1, Xian-Xian Yuan2, Nan Yang1, Li-Fei Gong1, Yue Tang1

 Lu-Lu Li1, Hai-He Yang1, Guang-Hui Li2,Yuan-Yuan Kong1*

Objective: To investigate the incidence and perinatal risk factors of congenital hypothyroidism (CH).

Methods: We conducted retrospective analysis of the data from Beijing Obstetrics and Gynecology hospital and Beijing Newborn Disease Screening Centre during 2016- 2021. A case-control study was adopted to select the children with CH as cases and their 1:1.5matched controls with the same gender, approximately the same birth date(±30days) was selected from the same population. Groups were compared using Chi-square, rank sum test and multi-factor logistic regression.

Results:1)A total of 82,628 neonates were screened between 2016-2021, 65 were diagnosed with CH(1:1272). 2)On Univariate analysis, compared with non-CH group, both the father’s age and serum TSH in early pregnancy were higher in CH group (c2/Z: 2.147 and 2.219, P < 0.05), both gestational age and birth weight were lower in CH group(c2/Z: -2.428 and -3.094, P < 0.05), higher proportion of preterm births, low birth weight and multiplets in CH group (c2/Z: 8.853,7.762 and 6.53P < 0.05).3)On Logistic regression analysis, serum TSH in early pregnancy(OR=1.676, 95%CI:1.073-2.618) and father’s age(OR=1.209,95%CI:1.077-1.358) were a perinatal risk factors of CH. In addition, birth weight (OR=0.999,95%CI:0.998-0.999) was protective factor.

Conclusion: The incidence of CH is high during the study period, which increased with the decreased birth weight. For infants with perinatal high risk factors such as Elevated serum TSH and father’s age, attention should be paid to assess thyroid function status dynamically.

Keywords: congenital hypothyroidism; birth weight; serum TSH; preterm; risk factors